Press Release

Shire plc News Alert Shire in-licenses JUVISTA(R) (human TGFâ3) from Renovo

20 June 2007

- Novel biopharmaceutical drug candidate for the prevention and reduction of scarring in connection with both therapeutic and cosmetic surgery – a market served by specialist physicians
- In-license includes exclusive worldwide rights except for EU member states
- Financial payments geared to success and linked to significant milestones
- Renovo estimates a potential new multi-billion market opportunity in the U.S.
 
Basingstoke, UK and Philadelphia, US – June 20, 2007 – Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) announced today the signing of an agreement with Renovo Group plc (LSE: RNVO) for the exclusive development and commercialization rights to JUVISTA(R), Renovo’s novel treatment in late phase 2 development for the prevention and reduction of scarring. Phase 3 trials are anticipated to commence in mid 2008.
 
Under the terms of the agreement Shire has the exclusive right to commercialize JUVISTA worldwide, with the exception of EU member states. 
 
To view the full announcement please visit our website http://www.shire.com and go to the Latest News.

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