Press Release

Shire Demonstrates Commitment To Improving Patient Adherence In End Stage Renal Disease As New Phosphate-Binder Fosrenol® Launches In Europe

BASINGSTOKE, UNITED KINGDOM (25 June 2007) Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ). New data from a patient adherence survey presented on Friday 22nd June at the XLIV ERA-EDTA Congress in Barcelona highlight that over 40% of patients with chronic kidney disease (CKD) forget to take their phosphate-binding medication.1 Phosphate binders are used to treat hyperphosphataemia (unusually high levels of phosphorous in the blood), which, if not managed successfully, can lead to serious health consequences including increased rates of cardiovascular morbidity and mortality and other complications.

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