Press Release

Shire Announces Posting of Circular, Date of Extraordinary General Meeting and Extension of Tender Offer for New River Shares until April 17, 2007

26 Mar 2007 - BASINGSTOKE, UK - March 26, 2007 – Shire plc (LSE: SHP.L; NASDAQ: SHPGY; TSX: SHQ) ("Shire" or the "Company") today announced the date of an Extraordinary General Meeting (“EGM”) of its shareholders to approve the proposed acquisition of New River Pharmaceuticals Inc. (NASDAQ: NRPH) ("New River"). The EGM will be held on April 16, 2007, at 12:00 noon BST at Financial Dynamics, Holborn Gate, 26 Southampton Buildings, London, WC2A 1PB.

Shire also announced today that its wholly owned subsidiary has extended its cash tender offer for all outstanding shares of New River common stock until the day after the date of the EGM as Shire shareholder approval of the acquisition at the EGM is one of the conditions to the tender offer. The tender offer, which had previously been scheduled to expire at 12:00 Midnight, New York City time, on March 29, 2007, has been extended until 12:00 Midnight, New York City time, on April 17, 2007.

Shire will today post a circular to its shareholders (the “Circular”) relating to its proposed acquisition of New River. A copy of the Circular, which contains the notice of the EGM, has been submitted to the UK Listing Authority and will shortly be available for inspection during normal business hours on any weekday (public holidays excepted) at the Document Viewing Facility, which is situated at the Financial Services Authority, 25 The North Colonnade, Canary Wharf, London E14 5HS, tel. +44 20 7066 1000. A copy of the Circular will also be made available at www.shire.com in the Events section.

As previously announced on February 20, 2007, Shire and New River signed a definitive agreement by which Shire has agreed to acquire each share of New River common stock for US, or approximately US.6 billion in total for the fully diluted equity interest of New River, in an all cash transaction unanimously recommended by the Boards of both companies.

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