Press Release

Results of Extraordinary General Meeting held on 16 April 2007

Shire plc (LSE: SHP.L; NASDAQ: SHPGY; TSX: SHQ) ("Shire" or the "Company") announced today that its shareholders approved the proposed acquisition of New River Pharmaceuticals Inc. (NASDAQ: NRPH) ("New River") at the Shire Extraordinary General Meeting held on 16 April 2007. The approval by Shire’s shareholders satisfies one of the conditions to the tender offer by Shire’s wholly owned subsidiary for all outstanding shares of New River common stock at a price of .00 per share, or approximately .6 billion in total for the fully diluted equity interest of New River. Consummation of the tender offer now remains subject only to certain customary conditions, including the valid tender of a majority of the outstanding New River shares on a fully diluted basis.

The tender offer will expire at 12:00 Midnight, New York City time, on Tuesday, April 17, 2007. The tender offer is being made pursuant to the previously announced agreement of merger among Shire, its wholly owned subsidiary and New River.

At the Extraordinary General Meeting, a resolution to approve the New River acquisition and to sanction an increase in the total borrowings of the Shire group of companies.

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