Press Release

IFRS results for the year ending December 31, 2006.

Basingstoke, UK – March, 23 2007 – Shire plc (“Shire”) (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ)  today publishes its preliminary results for the year ending December 31, 2006 in accordance with International Financial Reporting Standards (IFRS).

It should be noted that on February 20, 2006 Shire announced its results in respect of the same period in accordance with US GAAP.

For further information please contact:

Investor Relations Cléa Rosenfeld (Rest of the World) +44 1256 894 160
Eric Rojas (North America) +1 484 595 8252
Media Jessica Mann (Rest of the World) +44 1256 894 280
Matthew Cabrey (North America) +1 484 595 8248

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