Press Release

Full Year 2006 Results Date Notification - 23 February 2007

14 Feb 2007 - Basingstoke, UK and Philadelphia, US – 14 February 2007 – Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) will announce full year 2006 earnings on Friday 23 February 2007.

Results press release will be issued at: 12:00 GMT / 07:00 ET
Investor Meeting & conference call time: 14:00 GMT / 09:00 ET

Live analyst presentation and conference call:

Matthew Emmens, Chief Executive Officer and Angus Russell, Chief Financial Officer will host the investor and analyst meeting and live conference call at 14:00 GMT/9:00 ET. The venue for the meeting will be at the offices of Financial Dynamics, Holborn Gate, 26 Southampton Buildings, London WC2A 1PB

Please RSVP claire.rowell@fd.com for the live presentation.

Live conference call and Webcast:
The details of the live conference call and Webcast are as follows:

US Toll Free Dial In Number: 1 866 793 4279
UK Toll Free Dial In Number: 0800 358 2705
Standard International Dial In Number: +44 (0) 20 8609 0205
Conference ID / Pin Code: 292846#
Audio webcast: www.shire.com, in the Investor Relations/Events section

Please RSVP ssalah@shire.com for the conference call

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