Press Release

Executive Change

September 24, 2007 – Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ), the global specialty biopharmaceutical company, announced today that Sylvie Gregoire has been appointed President of its Human Genetic Therapies (HGT) business, effective immediately.

Sylvie brings more than 20 years of management, regulatory affairs, manufacturing and supply chain experience from biotechnology and pharmaceutical companies including Biogen Idec and Merck & Co. Sylvie replaces David Pendergast, former President of HGT, whose retirement was announced in March of this year.

To ensure a smooth transition, David will continue with Shire through 2007 as an advisor.

To view this announcement in full, please go to http://www.shire.com

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