Press Release

Excellent performance across all areas of the business and accelerating new product sales drive revenue growth of 36%

Basingstoke, UK and Philadelphia, US – February 21, 2008 – Shire plc (LSE: SHP, NASDAQ: SHPGY) the global specialty biopharmaceutical company announces results for the twelve months to December 31, 2007 – a year which has seen significant growth in launched products.

Financial Highlights:

2007 Full Year

  • Product sales up 41% to ,170m
  • New product sales 9m, 23% of product sales(1)
  • Total revenues up 36% to ,436m
  • Non GAAP Earnings per ADS up 38% to .95
  • US GAAP Earnings per ADS down 592% to -.06
  • Dividend up 20% (in US$ terms)

Q4 2007

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