Press Release

Brain scans could help predict schizophrenia

7th December 2006

Magnetic resonance imaging (MRI) scans have revealed changes in brain tissue in a small group of individuals before they developed schizophrenia.

The finding suggests that looking at changes in brain structure over time could help doctors to predict whether or not a person who has a family history of schizophrenia will go on to develop the illness.

The research, published today in BioMed Central Medicine, is part of the Medical Research Council funded Edinburgh High Risk study. For ten years, scientists at the University of Edinburgh followed 200 young people who were at a high risk of developing schizophrenia because two or more members of their family had already been diagnosed with the illness.

In this research, Dr Dominic Job of the University of Edinburgh analysed MRI scans of 65 of the 200 young people, taken on average 18 months apart. His team looked specifically for changes in grey matter; brain tissue made principally of neurones which transmit messages and help to store memories.

As members of a high risk group, each person in the study had approximately a 13% risk of developing schizophrenia. The MRI scans revealed changes in brain tissue that increased this prediction to 60% risk for some, thereby increasing clinicians’ ability to determine if an individual has an elevated risk.

Eight of the 65 young people (aged 16 – 25 at outset of study) went on to develop schizophrenia on average 2.3 years after their first scan. The MRI scans of each of these eight individuals revealed that they had changes in grey matter that happened before they became unwell.

Dr Job said: ‘‘Although there are no preventative treatments for the illness, an accurate predictive test could help researchers to assess possibilities for prevention in the future. Current methods are good for predicting who won’t develop schizophrenia but not who will. By combining brain imaging with traditional clinical assessments it might be possible to detect people who are at highest risk of the illness early.

‘‘But, because the number of participants in this study was small, the test needs to be independently replicated to confirm that MRI scanning to measure changes in grey matter is a reliable way to predict whether or not a person who is already at high risk, is even more likely to go on to develop schizophrenia.’’

Earlier this year, research from the Edinburgh study published in Nature Neuroscience reported that functional magnetic resonance imaging of the participants’ brains had helped scientists to link a version of the neuregulin gene to changes in brain activity that can lead to psychotic symptoms. To read visit: http://www.mrc.ac.uk/NewsViewsAndEvents/News/MRC003400

Key Facts

The average risk of a member of the UK population developing schizophrenia is less than 1%
The great majority of people who have schizophrenia are not a danger to other people
Schizophrenia is not a ‘split personality’ but rather a difficulty differentiating between reality and a person’s ‘inner’ world

To arrange an interview with Dr Dominic Job please contact the Medical Research Council press office on: 0207 637 6011 or press.office@headoffice.mrc.ac.uk Out of hours phone: 07818 428 297.

Alternatively contact Linda Menzies at the University of Edinburgh press office on: 0131 650 6382 or 0131 650 2250 or email: Linda.Menzies@ed.ac.uk

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