Shire sues Andrx Pharmaceuticals, L.L.C.

Basingstoke, UK and Philadelphia, US – November 10, 2006 – Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) announces that its subsidiary Shire Laboratories Inc. has filed lawsuits in the US District Court for the District of New Jersey and the Southern District of Florida against Andrx Pharmaceuticals, L.L.C. and Andrx Corporation (collectively “Andrx”) for infringement of Shire Laboratories’ US Patent Nos. 6,322,819 (‘the ‘819 Patent’) and 6,605,300 (‘the ‘300 Patent’).  Watson Pharmaceuticals, Inc., the recent acquirer of Andrx, is also being named in the lawsuits.

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